Unlock in order.
(1) First 6/7 cards gives you the power to kill ridden hordes. If you find a Machete you can avoid unlocking "Adrenaline Fueled" for now.
(2) Next 4 cards to let you tank every kind of damage in game ( 60% dmg reduction with Holly, no trauma resistance needed thanks to "face your fears"+"vanguard")
(3) When you unlock "Adrenaline Fueled" you can switch to the Purple/Blue Bat if your Machete haven't a good rarity (blue or purple).
(4) Last 4 cards let you kill also the mutations aiming the weakspots and let you kill hordes as fast as possible with the power of 60% dmg reduction, so at last you become leterally a god.
Edit: I don't like Mean Drunk 'cause I really appreciate to run out of combat in some cases like from witches, destroyers or running for an objective, etc... But obviously you can put that on the deck replacing "Natural Sprinter".
Edit 2: If you find a "Machete" you can Unlock "Berserker" before "Adrenaline Fueled" at your 6th card.