Dual purpose damage build - Shredder/Marked for death with any shotgun will deal with most smaller mutations;
Gearing towards a good Tac14 would be able to stun-lock any of the Reeker variants;
Heavily stacked grenade damage will delete tall boys and bosses;
Hyper-focused boosted secondaries should keep commons clear;
And enough speed is mixed in to flex on crescendo maps or general mobility.