If you've got a Combat Knife Holly or Pyro+Highwayman Hoff for common clear, consider this Sharice build focusing on maximum damage-per-swing to one-hit mutations.
Melee hits cause the target to deal 3% reduced damage, to a maximum of 15% reduced damage.
Quick Kill
offense
+ 50% Accuracy
DISABLES: Aim Down Sights
Heavy Attack
offense
Press [M2] with Melee weapons to perform a Heavy Attack.
Heavy Attacks deal 100% increased damage and expend 50% more Stamina.
Meth Head
offense
Each Melee swing grants 5% Melee Speed and 5% Melee Stamina Efficiency for 6 seconds, stacking up to 10 times.
Your Melee Attacks no longer stick in tough enemies.
DISABLES: Aim Down Sights
Hunker Down
defense
While crouching, gain 10% Damage Resistance and 40% Accuracy.
Sunder
offense
Melee hits cause the target to take 3% increased damage, to a maximum of 15% increased damage.
Melee hits that destroy Armor have a chance to create usable Makeshift Armor.
Motorcycle helmet
defense
+ 15% Damage Resistance
+ 10 Health
DISABLES: Aim Down Sights
